Chicken Pot Pie Casserole


Everyday Culinary Delights 👩‍🍳


Chicken Pot Pie Casserole is more than just a dish; it’s a warm hug on a cold day, a nostalgic trip to childhood memories, and a testament to the comfort food genre. This beloved classic combines tender chicken, creamy soup, and a medley of vegetables, all topped with a golden, biscuit crust. It’s a versatile recipe that allows for creativity but always results in a hearty, satisfying meal.

The origins of chicken pot pie can be traced back to the Greeks and Romans, but it was the American version, with its flaky pastry and creamy filling, that captured hearts. The casserole variation takes this tradition and simplifies it, making it an accessible option for busy weeknights without sacrificing flavor. For a deeper dive into the history of casseroles, this Wikipedia article provides a comprehensive overview.

Why do we consider chicken pot pie casserole the epitome of comfort food? It’s all in the ingredients and the way they come together to create something that’s both familiar and utterly delicious. The cream of chicken soup adds depth and creaminess, while the mixed vegetables bring color, texture, and nutrition. The cheddar cheese introduces a layer of gooey goodness that pairs perfectly with the garlic-infused biscuit topping. For those interested in exploring more about the role of cheese in cooking, check out this detailed list of cheeses.

In creating this dish, you’re not just cooking; you’re crafting an experience. It’s a meal that invites you to slow down, savor each bite, and appreciate the simple joys of homemade cuisine. Whether you’re a seasoned chef or a kitchen novice, chicken pot pie casserole is a recipe that welcomes all to the table with open arms and a promise of comfort.

Understanding the Ingredients 

The magic of Chicken Pot Pie Casserole lies in its ingredients, each bringing its unique flavor and texture to create a harmonious dish. Let’s break down the key components:

  • Chicken: The star of the dish, chicken provides protein and substance. Opting for cooked and shredded chicken not only saves time but also ensures each bite is infused with flavor. Whether you use leftovers or cook fresh chicken specifically for this recipe, the goal is tender, juicy meat that melds with the other ingredients.
  • Mixed Vegetables: A colorful medley of carrots, peas, green beans, and corn adds not just a variety of textures but also a boost of nutrition. Thawed for ease of mixing, these vegetables ensure that every spoonful of the casserole is balanced and vibrant.
  • Cream of Chicken Soup: This ingredient is crucial for the creamy base that defines the casserole. It envelops the chicken and vegetables in a rich, savory sauce that’s comforting and delicious. The soup also acts as a binder, ensuring the filling is cohesive and moist.
  • Cheddar Cheese: The inclusion of cheddar cheese adds a layer of complexity and richness. Its sharpness contrasts beautifully with the creaminess of the soup, while its meltability ensures a gooey, irresistible topping. For those curious about selecting the right type of cheese, this Wikipedia page offers valuable insights.

The Biscuit Topping is another critical component, providing a textural contrast to the creamy filling beneath. Made from a simple mix of Bisquick, milk, sour cream, melted butter, and minced garlic, this topping bakes to a golden brown, offering a slight crunch that complements the soft filling perfectly. The sour cream in the biscuit mix introduces a tangy note, balancing the richness of the dish, while the garlic adds a subtle warmth and depth of flavor. For those interested in the role of sour cream in baking, exploring various recipes can provide further inspiration.

Incorporating these ingredients thoughtfully not only ensures a delicious Chicken Pot Pie Casserole but also allows for a creative culinary process. Whether you’re sticking to the classic recipe or adding your twist, the key is to focus on quality ingredients that work well together. This dish is a celebration of simplicity and flavor, a reminder that sometimes the most straightforward recipes are the most satisfying.

Cooking Process 

The cooking process for Chicken Pot Pie Casserole is straightforward, making it an excellent choice for both novice cooks and seasoned chefs. Here’s a step-by-step guide to ensure your casserole turns out perfectly every time.

  • Preparation Steps: Begin by preheating your oven to 375°F (190°C), a crucial step for achieving the golden-brown crust that makes this dish so appealing. In a large mixing bowl, combine the cooked and shredded chicken with the cream of chicken soup, thawed mixed vegetables, and half of the shredded cheddar cheese. Season this mixture with salt and pepper to taste, ensuring every layer of your casserole is flavorful.
  • Layering the Casserole: Spread the chicken mixture evenly in a greased 9×13 inch baking dish. This size is ideal for ensuring the filling cooks evenly and the biscuit topping has enough surface area to brown beautifully. The even layering is key to a consistent texture and flavor in every bite.
  • Biscuit Topping Preparation: In another bowl, whisk together the milk, Bisquick mix, sour cream, melted butter, and minced garlic until smooth. This mixture should be creamy and free of lumps, ready to blanket the chicken layer with its rich, garlicky goodness. Pour the biscuit mixture over the chicken layer, spreading it out evenly to cover the entire surface.
  • Final Touches and Baking: Sprinkle the remaining cheddar cheese over the biscuit mixture, adding an extra layer of cheesy delight to the casserole. Bake in the preheated oven for 30-35 minutes. The exact time may vary depending on your oven, so look for the biscuit topping to become golden brown and the casserole to bubble around the edges, indicating it’s thoroughly cooked and ready to be enjoyed.
  • Cooling and Serving: Allow the casserole to cool for a few minutes before serving. This resting period helps the layers set, making it easier to cut and serve while ensuring the flavors meld beautifully.

This cooking process highlights the simplicity and comfort embodied in the Chicken Pot Pie Casserole. It’s a dish that doesn’t require intricate techniques or exotic ingredients but delivers a deeply satisfying and comforting meal. Whether you’re gathering around the table for a family dinner or looking for a cozy meal to warm up a chilly evening, this casserole promises to deliver warmth, comfort, and deliciousness in every bite.

Variations and Serving Suggestions 

Chicken Pot Pie Casserole is a versatile dish that can be adapted to suit various dietary preferences and occasions. Here are some creative variations and serving suggestions to enhance your casserole experience.


  • Vegetarian Options: For a vegetarian twist, replace the chicken with a mix of hearty vegetables like mushrooms, broccoli, and bell peppers, or use a plant-based chicken substitute. Incorporating a cream of mushroom soup instead of cream of chicken can also maintain the creamy consistency while keeping it vegetarian-friendly.
  • Gluten-Free Adaptations: To make this casserole gluten-free, use a gluten-free Bisquick mix and a gluten-free cream of chicken soup. These substitutions allow those with gluten sensitivities to enjoy the comfort of this classic dish without compromise. For more gluten-free casserole ideas, Pinterest offers a wealth of recipes to inspire your cooking.

Serving Suggestions

  • Side Dishes: Complement your Chicken Pot Pie Casserole with side dishes that balance its richness. A crisp green salad dressed with a light vinaigrette or steamed green beans can add a refreshing contrast to the meal. For a more substantial side, consider garlic mashed potatoes or roasted root vegetables.
  • Presentation Tips: Serve the casserole in the baking dish for a casual, family-style meal, or plate individual portions for a more formal presentation. Garnishing with fresh herbs like parsley or thyme not only adds a pop of color but also a fresh flavor that enhances the overall dish.

This casserole is a canvas for culinary creativity, allowing you to adjust the recipe to fit your taste preferences and dietary needs. Whether you’re serving it at a family dinner, potluck, or special occasion, Chicken Pot Pie Casserole is sure to be a crowd-pleaser. Remember, the essence of comfort food lies in its ability to bring people together, offering warmth and satisfaction with every bite.

Incorporating these variations and serving suggestions into your meal planning can elevate the humble chicken pot pie casserole from a simple weeknight dinner to a memorable meal that guests and family members alike will cherish. As you explore different adaptations, remember that the heart of this dish lies in its ability to be molded to your preferences while still retaining its comforting essence.

Nutritional Information 

Understanding the nutritional content of Chicken Pot Pie Casserole can help you incorporate this comforting dish into a balanced diet. While this casserole is undeniably comforting, it’s also packed with nutrients thanks to its variety of ingredients.

  • Caloric Content: A single serving of Chicken Pot Pie Casserole contains approximately 420 kcal. The majority of these calories come from the chicken, Bisquick mix, and cheddar cheese, providing a good balance of protein, carbohydrates, and fats.
  • Protein: Chicken, as the main ingredient, is an excellent source of high-quality protein, essential for muscle repair and growth. Each serving offers a substantial amount of protein, making this dish not only comforting but also nourishing.
  • Vegetables: The mixed vegetables in the casserole contribute vitamins and minerals, including vitamin A from carrots and vitamin C from green beans. These nutrients support immune function and overall health.
  • Dairy: The milk, cheese, and sour cream add calcium and vitamin D, crucial for bone health. They also contribute to the creamy texture and rich flavor of the casserole.

While Chicken Pot Pie Casserole is hearty and satisfying, it’s also a dish that, when consumed in moderation, can fit into a balanced diet. Pairing it with a side of leafy greens or a fresh salad can help balance the meal further, adding fiber and additional nutrients. For those interested in exploring the nutritional aspects of chicken further, this Wikipedia article provides detailed information.

In summary, Chicken Pot Pie Casserole is a nutrient-dense meal that offers a variety of vitamins and minerals. Its comforting nature doesn’t detract from its nutritional value, making it a worthwhile addition to your cooking repertoire.


Can the casserole be made ahead of time?

Yes, Chicken Pot Pie Casserole is an excellent make-ahead meal. Prepare the filling and biscuit topping, assemble in the baking dish, cover tightly, and refrigerate for up to 24 hours before baking. If baking from cold, add an extra 5-10 minutes to the cooking time. For freezer-friendly meal prep, assemble the casserole without baking, wrap well, and freeze. Thaw overnight in the refrigerator before baking as directed.

Best way to store and reheat leftovers?

Leftover Chicken Pot Pie Casserole can be stored in an airtight container in the refrigerator for up to 3 days. To reheat, cover with aluminum foil and warm in a 350°F oven until heated through, about 20 minutes. Alternatively, individual portions can be microwaved on medium power for 2-3 minutes, stirring halfway through to ensure even heating.

Tips for making a creamier filling?

For a creamier filling, consider adding an extra 1/4 cup of milk or a dollop of cream cheese to the chicken and vegetable mixture. Stirring in a tablespoon of all-purpose flour can also help thicken the sauce, enhancing its creamy texture. Additionally, ensure not to overbake the casserole, as the heat can cause the sauce to thin out.

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Chicken Pot Pie Casserole

  • Author: Ashely
  • Total Time: 55 minutes
  • Yield: 6 servings


This Chicken Pot Pie Casserole recipe is a comforting and hearty dish perfect for any day of the week. Combining tender shredded chicken, a medley of colorful vegetables, and a creamy sauce under a layer of cheesy garlic biscuit topping, it’s a modern twist on the classic chicken pot pie.


2 cups chicken, cooked and shredded
1 can (10.5 oz) cream of chicken soup
2 cups mixed vegetables (carrots, peas, green beans, corn), thawed
1 cup cheddar cheese, shredded
1 1/2 cups milk
1 cup Bisquick mix (for the biscuits)
1/2 cup sour cream
1/4 cup butter, melted
1 garlic clove, minced
Salt and pepper to taste


Preheat your oven to 375°F (190°C).
In a large mixing bowl, combine the cooked chicken, cream of chicken soup, mixed vegetables, and half of the cheddar cheese. Season with salt and pepper.
Spread the chicken mixture evenly in a greased 9×13 inch baking dish.
In another bowl, mix together the milk, Bisquick mix, sour cream, melted butter, and minced garlic until smooth.
Pour the biscuit mixture over the chicken layer, spreading it out evenly.
Sprinkle the remaining cheddar cheese over the top.
Bake in the preheated oven for 30-35 minutes, or until the biscuit topping is golden brown and the casserole is bubbly.
Let it cool for a few minutes before serving.


  • Make-Ahead Tips: Assemble the casserole up to a day in advance and store it in the refrigerator until ready to bake. This makes it a perfect option for busy days or when planning meals for the week.
  • Storage: Leftovers can be stored in the refrigerator for up to 3 days. For longer storage, freeze the casserole either baked or unbaked for up to 2 months. Thaw overnight in the refrigerator before reheating or baking.
  • Customization: Feel free to customize the vegetable mix based on preferences or what you have on hand. Similarly, the recipe can be adapted to be gluten-free or vegetarian, making it a versatile option for various dietary needs.
  • Serving Suggestion: Serve this casserole with a side of fresh salad or steamed vegetables to balance out the meal. A light, crisp salad can add a refreshing contrast to the rich and creamy casserole.
  • Nutritional Consideration: While indulgent, this casserole can fit into a balanced diet when served with nutrient-rich sides. For those monitoring their intake, consider using low-fat dairy options or increasing the proportion of vegetables to chicken.
  • Prep Time: 20 minutes
  • Cook Time: 35 minutes
  • Category: Chicken
  • Cuisine: American


  • Calories: 420 kcal

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